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[Solovir_Rendering.tif]
Image: SoloVir™ Electrokinetic Transdermal System (ETS)
Caption: Transport’s SoloVir™ Electrokinetic Transdermal System (ETS) product targets herpes labialis, commonly called cold sores. The SoloVir ETS drives a large bolus of drug into the skin, breaking the barrier of the dermis and creating an intradermal drug depot in a single treatment.
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Image: The Process of Electrokinetic Drug Delivery
Caption: Electrokinetic drug delivery utilizes a low-voltage electric current to induce fluid and particle movement. Iontophoresis, a type of electrokinetic delivery, involves the application of an electromotive force to transport ions and neutral molecules through a solid or liquid medium, in this case the skin’s protective stratum corneum, and into the epidermis.
[Traditional_Dermal_Drug_Depot.tif]
Image: Traditional Topical Dermal Drug Treatment
Caption: In the conventional approach to dermal drug treatment, a topical drug slowly permeates the skin through passive diffusion. Arrow vectors represent movement of drug.
[SoloVir™_ETS_Dermal Drug Depot.tif]
Image: SoloVir™ ETS Dermal Drug Depot
Caption: Transports SoloVir ™ Electrokinetic Transdermal System (ETS) creates an intradermal drug depot with the first treatment. Transport’s ETS saturates the stratum corneum and epidermis with a drug in a single, 10-minute treatment. Arrow vectors represent movement and volume of drug.
[Self_Administration_with_Solovir.tif]
Image: (Woman self-administering with SoloVir™ ETS)
Caption: Transport’s Electrokinetic Transdermal System (ETS) consists of a reusable inotophoretic control unit and a disposable, unit-dose, single-use, pre-filled cartridge. The small, wireless control unit uses a low-voltage, which is varied in response to patient skin impedance to provide constant current and control of drug delivery. The drug delivery cartridge contains a unit dose of the proprietary drug formulation, as well as the drug delivery electrode. Portability of the battery-powered device allows patients to easily self-administer tropical drugs for a variety of indications.
[Herpes_Labialis_Life_Cycle.tif]
Image: Herpes Labialis Life Cycle
Caption: Cold sores have a distinct life cycle which can last 10-12 days. Day one is characterized by prodrome, a burning or tingling in the skin, which is an early indication of the onset of a herpetic episode. Prodromal symptoms occur in about 30 percent of herpes sufferers. The next stage is an erythema, a redness and bump in the skin, followed by papules, small conical elevations of the skin. These first stages are usually completed within the first 24 hours. A vesicle, or blister, appears the second day, which then breaks open to form an ulcer on day three. A soft/hard crust, the first sign of healing, appears on days three through eight, followed by a dry flaking and swelling of the skin on days eight through ten. The crust then falls off and the redness slowly subsides with a return to normal skin.
[Transport_Logo.tif]
Image: Transport Logo
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